Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome

Autor: Dominic C Chow, Anne Tasaki, Jill Ono, Bruce Shiramizu, Scott A Souza
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Zdroj: Biologics: Targets & Therapy, Vol 2008, Iss Issue 4, Pp 917-921 (2008)
Druh dokumentu: article
ISSN: 1177-5475
1177-5491
Popis: Dominic C Chow, Anne Tasaki, Jill Ono, Bruce Shiramizu, Scott A SouzaHawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USABackground: HIV-associated lipodystrophy syndrome is strongly associated with antiretroviral treatment in patients with human immunodeficiency virus (HIV). Niacin is thought to affect hormone-sensitive lipase (HSL) and lipoprotein lipase (LPL) expression in peripheral and intra-abdominal fat (IAF).Objective: This study investigated the effect of extended-release niacin (ERN) on adipose HSL and LPL expression in patients with HIV-associated lipodystrophy syndrome.Methods: Changes in IAF and peripheral fat content and HSL and LPL expression were examined in 4 HIV-infected patients recruited from a prospective study treated with ERN. Patients underwent limited 8 slice computerized tomography abdominal scans, dual-energy X-ray absorptiometry scans, and skin punch biopsies of the mid-thigh at baseline and after 12 weeks of ERN. All subjects were on stable highly active antiretroviral therapy prior to and during the study. Changes in body habitus were self-reported.Results: Normalized HSL expression decreased in 3 patients and normalized LPL expression increased in all 4 patients when comparing pre- and post-ERN treated samples. All subjects showed a decrease in total cholesterol (TC) and triglyceride (TG) levels.Conclusions: Preliminary analysis suggests ERN may induce changes in HSL and LPL expression. This method is a feasible approach to identify changes in adipose RNA expression involved with lipolysis.Keywords: extended-release niacin, HIV, lipodystrophy syndrome, hormone-sensitive lipase (HSL), lipoprotein lipase (LPL)
Databáze: Directory of Open Access Journals
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