COX-2 induces T cell accumulation and IFN-γ production during the development of chromium allergy

Autor: Ratri Maya Sitalaksmi, Koyu Ito, Kouetsu Ogasawara, Yoshiko Suto, Madoka Itabashi, Kyosuke Ueda, Noriyasu Hirasawa, Takayuki Narushima, Nike Hendrijantini, Utari Kresnoadi, Keiichi Sasaki
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Autoimmunity, Vol 52, Iss 5-6, Pp 228-234 (2019)
Druh dokumentu: article
ISSN: 0891-6934
1607-842X
08916934
DOI: 10.1080/08916934.2019.1662404
Popis: Chromium (Cr) is commonly added into various metal alloys to improve some mechanical properties such as corrosion resistance, strength, and workability. However, Cr is also known to be a metal allergen for some individuals. Metal allergy is a T cell-mediated disease with symptoms of inflammation and swelling that involve inflammatory cytokines and prostaglandins. Hence, suppressing these inflammation paths by using COX-2 inhibitor might be useful in treating Cr allergy. In this study, mice were used with Cr-induced allergy challenge model. The mice were injected with celecoxib once per day for 7 days one hour after the challenge. Footpad samples were stained with haematoxylin and eosin (H&E), and lymphocytes were isolated from popliteal lymph nodes for the flow cytometric analysis. The results show that both prostaglandin E2 (PGE2), a known mediator of inflammation, and cyclooxygenases (COX)-2 have important roles in the development of Cr allergy. Further, COX-2 inhibitor, celecoxib, was effective in relieving swelling and inflammation in Cr-allergic mice concordant with suppression of IFN-γ production by CD8+ T cells and T cell accumulation in the lymph nodes. Therefore, the inhibition of COX-2 may be a therapeutic target for Cr allergy, and additional molecules in the PGE2 signalling pathway may also be an effective therapeutic target for the treatment of metal allergy.
Databáze: Directory of Open Access Journals
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