Evaluation of Therapies for Secondary Hyperparathyroidism Associated with Vitamin D Insufficiency in Chronic Kidney Disease
| Autor: | Stephen A. Strugnell, Philipp Csomor, Akhtar Ashfaq, Charles W. Bishop |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Kidney Diseases (2023) |
| Druh dokumentu: | article |
| ISSN: | 2296-9381 2296-9357 |
| DOI: | 10.1159/000529523 |
| Popis: | Abstract Introduction: Parathyroid hormone-lowering responses after administration of three different therapies capable of raising serum total 25-hydroxyvitamin D (25OHD) were evaluated in patients with secondary hyperparathyroidism (SHPT), vitamin D insufficiency (VDI) and stage 3 or 4 chronic kidney disease (CKD). Methods: Sixty-nine adult subjects with intact parathyroid hormone (iPTH) ≥85 and 5.5 mg/dL) occurred once with ERC, eight times with HDC, three times with IRC and twice with PLDC. Conclusion: ERC was highly effective in both raising serum 25OHD and decreasing iPTH in patients with SHPT, VDI and stage 3 or 4 CKD. iPTH-lowering response rates with ERC were similar to daily PLDC, the reference therapy; rates with IRC or HDC were significantly lower. ERC is an attractive alternative to vitamin D hormone therapy in CKD patients. |
| Databáze: | Directory of Open Access Journals |
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