| Autor: |
Mariana Grancieri, Neuza Maria Brunoro Costa, Maria das Graças Vaz Tostes, Daniela Silva de Oliveira, Louisiane de Carvalho Nunes, Letícia de Nadai Marcon, Thaísa Agrizzi Veridiano, Mirelle Lomar Viana |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 37, Iss , Pp 666-675 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2017.08.039 |
| Popis: |
Yacon flour (YF) (Smallanthus sonchifolius) is source of fructooligosaccharides (FOS) which are prebiotic with effects unknown in the colorectal cancer (CRC). This study investigated the intestinal effects of supplementation with 7.5% FOS from YF for 8 weeks on CRC induced by 1.2-dimethylhydrazine (25 mg/kg/body weight) in male Wistar rats. The animals were divided in groups: S (without YF and without induced CRC, n = 10), Y (with YF and without induced CRC, n = 10), C (without YF and with induced CRC, n = 10) and CY (with YF and with induced CRC, n = 10). The animals that received YF had a percentage reduction of aberrant crypts focus in more than 40%, lower intestinal permeability, luminal content more acidic and with higher concentrations of SCFA. In addition, there was an increase in the depth and number of colonic crypts. In conclusion, we observed that YF promoted beneficial effects on the intestinal health of animals with induced CRC. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect