CapeOX as neoadjuvant chemotherapy for locally advanced rectal cancer: might less be more?

Autor:	Tianan Guo, Kai Liu, Yang Guo, Huan Zhang, Zhonglin Zhu, Dan Huang, Sanjun Cai, Tong Tong, Xiaoyan Zhou, Ye Xu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Neoadjuvant chemotherapy Locally advanced rectal cancer CapeOX MRI-TRG NAR score Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 24, Iss 1, Pp 1-9 (2024)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-024-12972-6
Popis:	Abstract Background Locally advanced rectal cancer (LARC) poses unique challenges in treatment, with current neoadjuvant chemoradiotherapy (NA-CRT) showing limitations. The CapeOX regimen emerges as a potential less aggressive neoadjuvant chemotherapy (NAC) for LARC. Methods We conducted a retrospective study involving treatment-naïve patients with LARC from March 2014 to March 2021 who received 2–4 cycles of CapeOX NAC followed by radical surgery. Treatment response was evaluated using tumor regression grade (TRG), MRI-based TRG (MRI-TRG), and Neoadjuvant Rectal (NAR) score. Results 94.7% of patients experienced symptom improvement and 96.4% achieved sphincter-preserving surgery. Post-NAC showed significant tumor regression and MRI confirmed a tumor length reduction (P
Databáze:	Directory of Open Access Journals
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