Delirium in Children Undergoing Hematopoietic Cell Transplantation: A Multi-Institutional Point Prevalence Study
| Autor: | Chani Traube, Linda M. Gerber, Elizabeth A. Mauer, Keshia Small, Larisa Broglie, Yogi Raj Chopra, Christine N. Duncan, Christen L. Ebens, Julie C. Fitzgerald, Jason L. Freedman, Michelle P. Hudspeth, Caitlin Hurley, Kris M. Mahadeo, Jennifer McArthur, Miriam C. Shapiro, Matthew P. Sharron, Donna A. Wall, Matt S. Zinter, Bruce M. Greenwald, Gabrielle Silver, Farid Boulad |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Frontiers in Oncology, Vol 11 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2234-943X 11446919 |
| DOI: | 10.3389/fonc.2021.627726 |
| Popis: | Introduction: Delirium occurs frequently in adults undergoing hematopoietic cell transplantation, with significant associated morbidity. Little is known about the burden of delirium in children in the peri-transplant period. This study was designed to determine delirium rates, define risk factors (demographic and treatment related), and establish feasibility of multi-institutional bedside screening for delirium in children undergoing hematopoietic cell transplant.Methods: This is a multi-institutional point prevalence study. All subjects were prospectively screened for delirium twice daily using the Cornell Assessment of Pediatric Delirium over a 10-day period. De-identified data, including basic demographics and daily characteristics, were extracted from the electronic medical record.Results: Eleven North American institutions were included, 106 children were enrolled, and 883 hospital days were captured. Delirium screening was successfully completed on more than 98% of the study days. Forty-eight children (45%) developed delirium over the course of the 10-day study. Children were diagnosed with delirium on 161/883 study days, for an overall delirium rate of 18% per day. Higher delirium rates were noted in children |
| Databáze: | Directory of Open Access Journals |
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