The gut microbiota modulates brain network connectivity under physiological conditions and after acute brain ischemia
| Autor: | Markus Aswendt, Claudia Green, Rebecca Sadler, Gemma Llovera, Lauren Dzikowski, Steffanie Heindl, Mercedes Gomez de Agüero, Michael Diedenhofen, Stefanie Vogel, Frederique Wieters, Dirk Wiedermann, Arthur Liesz, Mathias Hoehn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | iScience, Vol 24, Iss 10, Pp 103095- (2021) |
| Druh dokumentu: | article |
| ISSN: | 2589-0042 61948349 |
| DOI: | 10.1016/j.isci.2021.103095 |
| Popis: | Summary: The gut microbiome has been implicated as a key regulator of brain function in health and disease. But the impact of gut microbiota on functional brain connectivity is unknown. We used resting-state functional magnetic resonance imaging in germ-free and normally colonized mice under naive conditions and after ischemic stroke. We observed a strong, brain-wide increase of functional connectivity in germ-free animals. Graph theoretical analysis revealed significant higher values in germ-free animals, indicating a stronger and denser global network but with less structural organization. Breakdown of network function after stroke equally affected germ-free and colonized mice. Results from histological analyses showed changes in dendritic spine densities, as well as an immature microglial phenotype, indicating impaired microglia-neuron interaction in germ-free mice as potential cause of this phenomenon. These results demonstrate the substantial impact of bacterial colonization on brain-wide function and extend our so far mainly (sub) cellular understanding of the gut-brain axis. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|