| Autor: |
Yiqin Chen, Fangyuan Guan, Panlin Wang, Weili Liu, Wenhui Zhang, Han Sun, Lingling Zhu, Yanxin Huang, Yan Sun, Wenxiang Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Ecotoxicology and Environmental Safety, Vol 264, Iss , Pp 115414- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0147-6513 |
| DOI: |
10.1016/j.ecoenv.2023.115414 |
| Popis: |
Environmental copper (Cu) contamination is a complex worldwide public health problem. However, information on the effects of Cu pollution on human reproduction is limited. Although our previous studies have indicated that Cu exposure disrupts ovarian folliculogenesis, the underlying mechanism needs to be further explored. In this study, human luteinized ovarian granulosa cells and a rat animal model were used to investigate whether Cu exposure affects ovarian follicle development by inducing apoptosis and to elucidate the possible mechanisms. The results showed that Cu exposure from weaning to sexual maturity significantly decreased the proportion of preantral follicles but increased the proportion of atretic follicles (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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