Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons

Autor: Tina Pekec, Jarosław Lewandowski, Alicja A. Komur, Daria Sobańska, Yanwu Guo, Karolina Świtońska-Kurkowska, Jędrzej M. Małecki, Abhishek Anil Dubey, Wojciech Pokrzywa, Marcin Frankowski, Maciej Figiel, Rafal Ciosk
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-32500-z
Popis: Strategies to improve cold resistance are of potential biomedical interest. Here the authors demonstrate that ferritin-mediated detoxification of iron, preventing the generation of reactive oxygen species, promotes cold survival in both Caenorhabditis elegans and cultured mammalian neurons.
Databáze: Directory of Open Access Journals