| Autor: |
Patricia González Ildefonso, Ana Belén Nieto Librero, Montserrat Martín Alonso, María Luisa Hernández Cerceño, Esther García Serrano, Pablo Prieto-Matos |
| Jazyk: |
Spanish; Castilian |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Anales de Pediatría (English Edition), Vol 98, Iss 5, Pp 329-337 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2341-2879 |
| DOI: |
10.1016/j.anpede.2023.04.001 |
| Popis: |
Introduction: The acid-labile subunit (ALS) plays an important role in the endocrine effects of insulin-like growth factors (IGFs) on target tissues. Historically, it has attracted limited attention. The aim of our study was to describe the normal range of ALS in healthy children and its association with other growth factors. Patients and methods: We designed a cross-sectional descriptive study. We collected data on age, height, body mass index, gestational age, anthropometry at birth and serum levels of ALS, IGF1 and IGFBP3 in healthy children aged 2–15 years with a normal height. The levels of ALS, IGF1 and IGFBP3 were measured by ELISA. We fitted GAMLSS normalization models to standardize the variables. Results: Samples were collected from 446 children. In prepubertal children, the levels of ALS, IGF1 and IGFBP3 were positively correlated in both sexes and with age (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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