Phospholipid, arachidonate and eicosanoid signaling in schizophrenia

Autor:	Messamore Erik, Yao Jeffrey K.
Jazyk:	English<br />French
Rok vydání:	2016
Předmět:	Phospholipids arachidonic acid eicosanoids niacin-induced flushing endophenotype marker schizophrenia Oils fats and waxes TP670-699
Zdroj:	Oilseeds and fats, crops and lipids, Vol 23, Iss 1, p D112 (2016)
Druh dokumentu:	article
ISSN:	2272-6977 2257-6614
DOI:	10.1051/ocl/2015054
Popis:	This paper reviews the potential role of arachidonic acid in the pathophysiology of schizophrenia. We discuss how abnormal levels of arachidonic acid may arise, and how dysregulation of signaling molecules derived from it have the potential to disrupt not only dopamine signaling, but numerous other physiological processes associated with the illness. Pharmacological doses of niacin stimulate the release of arachidonic acid; and arachidonic acid-derived molecules in turn dilate blood vessels in the skin. A blunted skin flush response to niacin is reliably observed among patients with schizophrenia. The niacin response abnormality may thus serve as a biomarker to identify a physiological subtype of schizophrenia associated with defective arachidonic acid-derived signaling.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3da9fa96cf7744ad82dd21fb0b65c0de Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF