Fasting and postprandial trimethylamine N‐oxide in sedentary and endurance‐trained males following a short‐term high‐fat diet

Autor: Cortney N. Steele, Mary Elizabeth Baugh, Laura E. Griffin, Andrew P. Neilson, Brenda M. Davy, Matthew W. Hulver, Kevin P. Davy
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Physiological Reports, Vol 9, Iss 16, Pp n/a-n/a (2021)
Druh dokumentu: article
ISSN: 2051-817X
49923544
DOI: 10.14814/phy2.14970
Popis: Abstract Gut bacteria release trimethylamine (TMA) from dietary substrates. TMA is absorbed and is subsequently oxidized in the liver to produce trimethylamine N‐oxide (TMAO). Plasma TMAO levels are positively correlated with risk for type 2 diabetes (T2D) and cardiovascular disease (CVD). High‐fat diet (HFD) consumption has been reported to increase fasting and postprandial TMAO in sedentary individuals. However, whether the increase in TMAO with consumption of an HFD is observed in endurance‐trained males is unknown. Healthy, sedentary (n = 17), and endurance‐trained (n = 7) males consumed a 10‐day eucaloric diet comprised of 55% carbohydrate, 30% total fat, and 0.05) in the sedentary and endurance‐trained group, respectively. VO2max was significantly higher in the endurance‐trained compared with sedentary males (56.7 ± 8.2 vs. 39.9 ± 6.0 ml/kg/min). Neither the HFC nor the HFD evoked a detectable change in plasma TMAO (p > 0.05) in either group. Future studies are needed to identify the effects of endurance training on TMAO production.
Databáze: Directory of Open Access Journals
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