| Autor: |
Juanjuan Guo, Su Han, Xu Lu, Zebin Guo, Shaoxiao Zeng, Xiuhua Zheng, Baodong Zheng |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 57, Iss , Pp 335-344 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2019.04.029 |
| Popis: |
κ-Carrageenan hexamer (KCH, α-DA-1 → 3-β-G4S-1 → 4-α-DA-1 → 3-β-G4S-1 → 4-α-DA-1 → 3-G4Srα/β) are negatively charged sulfated oligosaccharides that demonstrate broad-spectrum immunoregulatory activities. However, the functional mechanism and interaction sites of KCH with recognition proteins have not been elucidated. The study aimed to investigate the anti-inflammatory signaling pathways and expound the mechanism of KCH competing with LPS in LPS-induced RAW264.7 macrophages. Expression of cytokines (NO, TNF-α, IL-β, IL-8), genes (mTNF-α, mIL-β, mIL-8) and proteins (iNOS, COX-2) involved in inflammation were significantly suppressed (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect