Porcine beta defensin 2 attenuates inflammatory responses in IPEC-J2 cells against Escherichia coli via TLRs-NF-κB/MAPK signaling pathway

Autor:	Xiaoyang Shen, Mingke Gu, Fengting Zhan, Hanfang Cai, Kun Zhang, Kejun Wang, Chunli Li
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Porcine beta defensin 2 Immunomodulatory function Inflammatory responses TLRs signaling pathway E. coli Veterinary medicine SF600-1100
Zdroj:	BMC Veterinary Research, Vol 20, Iss 1, Pp 1-11 (2024)
Druh dokumentu:	article
ISSN:	1746-6148
DOI:	10.1186/s12917-024-04220-7
Popis:	Abstract Background Porcine beta defensin 2 (pBD2) is one of the porcine beta defensins that has antibacterial activity, and plays an important role in the immunomodulatory activity that protects cells from pathogens. It has been reported that pBD2 plays their immunomodulatory functions related to the TLR4-NF-κB signal pathways. However, it is not completely clear how pBD2 reduces the inflammatory response caused by pathogens. Results In this study, the effect of pBD2 on the expression of genes in the TLRs signaling pathway was investigated after IPEC-J2 cells were challenged with E. coli. The results showed that pBD2 decreased the expression of IL-8 induced by E. coli (P
Databáze:	Directory of Open Access Journals
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