Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis

Autor: Xiangping Huang, Ling Wu, Qianhui Ouyang, Ying Huang, Lanhui Hong, Sixiang Liu, Kongzhi Yang, Ding Ning, Chao Chao Tan
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 1479-5876
DOI: 10.1186/s12967-024-04901-9
Popis: Abstract Objective Infectious pancreatic necrosis (IPN) is a serious complication of acute pancreatitis, and early recognition and timely intervention are the keys to improving clinical outcomes. The purpose of this study was to investigate the predictive capacity of the neutrophil CD64 index (nCD64 index) on IPN in patients with acute pancreatitis Methods This study comprises two independent cohorts: the training cohort consisted of 202 patients from Hunan Provincial People's Hospital, and the validation cohort consisted of 100 patients from Changsha Central Hospital. Peripheral blood samples were collected on the day of admission and on the 3rd, 5th, 7th, and 10th days of hospitalization, and the nCD64 index was detected by flow cytometry. Additionally, relevant clinical characteristics and laboratory biomarkers were collected and analyzed. Results We observed that nCD64 index on admission was significantly higher in the IPN group than Non-IPN group (p
Databáze: Directory of Open Access Journals
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