Serum soluble intercellular adhesion molecule-1 (sICAM-1): A novel potential biomarker in severe acne vulgaris

Autor: Amany Ibrahim Mustafa, Adel Ali Ebrahim, Waleed Abdel Lateef Abel Halim, Eman Fawzy, Ahmed Fathy Abdou
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Indian Journal of Dermatology, Vol 67, Iss 5, Pp 512-517 (2022)
Druh dokumentu: article
ISSN: 0019-5154
1998-3611
DOI: 10.4103/ijd.ijd_387_21
Popis: Background: Acne vulgaris (AV) is a chronic inflammatory disorder. Intercellular adhesion molecule-1 (ICAM-1) is a vital adhesion molecule mediating cellular adhesion during the inflammatory process. Aims and Objectives: To evaluate serum soluble intercellular adhesion molecule-1 (sICAM-1) level in AV patients as an attempt to elucidate its role in acne pathogenesis and to relate with studied clinical parameters. Materials and Methods: Serum sICAM-1 level was measured using ELISA technique in 60 patients and 60 controls. Results: Serum sICAM-1 level was significantly elevated in studied patients than controls (P < 0.001). Additionally, its level increased significantly with increased acne severity (P < 0.001) but not in patients with post acne scars (P > 0.05). Conclusion: Serum sICAM-1 could be a marker for acne etiopathogenesis. Furthermore, it might be considered as a predictor for disease severity.
Databáze: Directory of Open Access Journals
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