| Autor: |
Felipe Francisco Tuon, MD, PhD, Margot Kruger, MD, Marcos Terreri, MD, Sergio R. Penteado-Filho, MD, Lucas Gortz, MSc |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Brazilian Journal of Infectious Diseases, Vol 15, Iss 6, Pp 594-598 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1413-8670 |
| DOI: |
10.1016/S1413-8670(11)70257-4 |
| Popis: |
Background: Extended spectrum β-lactamase (ESBL)-producing bacteria have become recognized as a problem in South America. The aim of this study was to evaluate risk factors and mortality rate in bacteremia caused by ESBL-producing Klebsiella pneumoniae in a Brazilian hospital. Methods: A three-year retrospective cohort study with 104 cases of K. pneumoniae bacteremia (61 ESBL and 43 non-ESBL). Several clinical and laboratory variables were evaluated. The outcome of interest was 30-day mortality. The adequate treatment was evaluated according to antibiotic susceptibility. Results: Multivariable analysis showed that central venous catheter and mechanical ventilation were independent risk factors for ESBL. The duration of hospitalization before the bacteremia was not a risk factor. Mortality was similar in ESBL and non-ESBL and inadequate therapy was not shown to be a risk factor. Conclusion: ESBL-producing Klebsiella bacteremia can occur early, suggesting that a carbapenem should be included in the initial empirical therapy for bacteremia in patients under mechanical ventilation and/or central venous catheter in our institution. Keywords: Klebsiella pneumoniae, beta-lactamases, bacteremia, carbapenems |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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