| Autor: |
Kazuki Hara, Tatsuya Beppu, Masahiko Kimura, Yoshihiko Fujita, Toshikazu Takata, Kazuto Nishio, Nobufumi Ono |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 122, Iss 2, Pp 153-157 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.12244SC |
| Popis: |
We studied the influence of novel supramolecular substance, [2] rotaxane (TRO-A0001), on caspase signaling and cell viability in cancer cell lines. TRO-A0001 suppressed concentration-dependently cell proliferation. Expression of the cleaved-form caspase-3 and PARP was significantly increased in cells exposed to TRO-A0001. The expression of Bax was increased by TRO-A0001. Furthermore, the down-regulation of Bax by siRNA resulted in growth activation significantly. The morphological analysis demonstrated that TRO-A0001 increased the levels of apoptotic cells in human cancer cell lines. These results suggest that TRO-A0001 induces apoptosis in cancer cells and holds potential as a new anti-tumor medicine. Keywords:: [2] rotaxane, supramolecular compound, apoptosis |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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