Fanconi syndrome due to prolonged use of low-dose adefovir
| Autor: | Xiao-Bing Wang, Xiao-Chun Zhu, Xiao-Ying Huang, Wen-Jing Ye, Liang-Xing Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Journal of Research in Medical Sciences, Vol 20, Iss 4, Pp 416-419 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1735-1995 1735-7136 |
| Popis: | Fanconi syndrome results from a generalized abnormality of the proximal tubules of the kidney and owing to phosphate depletion can cause hypophosphatemic osteomalacia. Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus replication but exhibits nephrotoxicity when administered at a low dosage. We report two cases of Fanconi syndrome induced by ADV at 10 mg/day to call for regular screening for evidence of proximal tubular dysfunction and detailed bone metabolic investigations for prompt detection of ADV nephrotoxicity is critically important to ensure timely drug withdrawal before the development of irreversible tubulointerstitial injury. |
| Databáze: | Directory of Open Access Journals |
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