| Autor: |
Volkan Hazar, Gülsün Karasu, Vedat Uygun, Mediha Akcan, Alphan Küpesiz, Akif Yeşilipek |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Turkish Journal of Hematology, Vol 29, Iss 2, Pp 143-149 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1308-5263 |
| DOI: |
10.5505/tjh.2012.78300 |
| Popis: |
OBJECTIVE: The aim of this study was to document hematopoietic stem cell transplantation (HSCT) activity and trends at our treatment center. METHODS: Data collected over a 10-year period were retrospectively analyzed, concentrating primarily on types of HSCT, transplant-related mortality (TRM), stem cell sources, indications for HSCT, and causes of death following HSCT. RESULTS: In total, 222 allogeneic (allo)-HSCT (87.4%) and 32 autologous (auto)-HSCT (12.6%) procedures were performed between 1998 and 2008. Stem cells obtained from unrelated donors were used in 22.6% (50/222) of the allo- HSCTs. Cord blood was the source of hematopoietic stem cells (HSC) in 12.2% of all transplants. The most common indication for allo-HSCT was hemoglobinopathy (43.2%), versus neuroblastoma (53.1%) for auto-HSCT. The TRM rate 1 year post transplantation was 18.3% +- 2.5% for all transplants, but differed according to transplantation type (23.5% +- 7.9% for auto-HSCT and 17.5% +- 2.6% for allo-HSCT). The most common cause of death 1 year post HSCT was infection (35.9%). CONCLUSION: The TRM rate in the patients that underwent allo-HSCT was similar to that which has been previously reported; however, the TRM rate in the patients that underwent auto-HSCT was higher than previously reported in developed countries. The selection of these patients to be transplanted must be made attentively. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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