Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data

Autor: Nicole M. Warrington, Liang-Dar Hwang, Michel G. Nivard, David M. Evans
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-25723-z
Popis: Estimating direct and indirect effects of genotypes on phenotypes is important for genetic analyses such as Mendelian randomization. Here the authors compare five different methods to estimate direct and indirect genetic effects using summary results statistics that account for sample overlap.
Databáze: Directory of Open Access Journals