Tacrolimus for Remission Induction and Maintenance Therapy in Patients with Ulcerative Colitis: A Retrospective Evaluation Study

Autor:	Ayumi Ito, Bunei Iizuka, Teppei Omori, Shinichi Nakamura, Katsutoshi Tokushige
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	Gastroenterology Research and Practice, Vol 2016 (2016)
Druh dokumentu:	article
ISSN:	1687-6121 1687-630X
DOI:	10.1155/2016/5956316
Popis:	Background. In this retrospective study, we compared the efficacy of tacrolimus (TAC) or prednisolone (PSL) for maintenance therapy in patients with ulcerative colitis (UC) at remission. Methods. The study patients were followed up for at least one year after induction of remission with either PSL (n=55, between April 2004 and March 2014) or TAC (n=40, between April 2009 and March 2014). The clinical features and relapse rates were compared in the two groups. Maintenance therapy in the TAC group included TAC alone, AZA alone, and TAC plus AZA. Results. The recurrence rates at 1500 days after remission were 61% and 46% for the PSL and TAC groups, respectively (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c3b63eaa42ec486fabca8a07da06df69 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF