Safety and Efficacy of Tranexamic Acid in Spinal Surgery: A Systematic Review and Meta-Analysis
| Autor: | Kento Yamanouchi, Haruki Funao, Naruhito Fujita, Shigeto Ebata, Mitsuru Yagi |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Spine Surgery and Related Research, Vol 8, Iss 3, Pp 253-266 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2432-261X 16027345 |
| DOI: | 10.22603/ssrr.2023-0244 |
| Popis: | Background: Tranexamic acid (TXA) has gained popularity in spinal surgery because of its potential to reduce blood loss. However, concerns regarding its safety and efficacy remain. This systematic review and meta-analysis aimed to evaluate the efficacy of TXA in reducing blood loss and its safety profile in spinal surgeries. Methods: A comprehensive search was conducted in electronic databases for randomized controlled trials and prospective studies evaluating the use of TXA in spinal surgery. The primary outcomes were intraoperative and total estimated blood loss (EBL), and the secondary outcomes included the incidence and types of complications associated with TXA use. Meta-analyses were performed using random-effects models. Results: Thirteen studies involving 1,213 participants were included in the meta-analysis. The use of TXA was associated with significant reductions in both intraoperative (mean difference: −46.56 mL [−73.85, −19.26], p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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