| Autor: |
Helena Tydén, Anders A Bengtsson, Christian Lood, Bobby Kwanghoon Han, Katherine D Wysham, Kevin C Cain |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Lupus Science and Medicine, Vol 7, Iss 1 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2053-8790 |
| DOI: |
10.1136/lupus-2020-000382 |
| Popis: |
Objective Neutrophils contribute to the SLE pathogenesis. Neutrophil to lymphocyte ratio (NLR) is reported to correlate with disease activity in SLE. The aim of the study was to evaluate whether NLR reflects underlying immunopathogenic activity in SLE, as well as to determine the contribution of each component of NLR, neutrophil and lymphocyte count.Methods Data were obtained from a cohort of patients with SLE (n=141) recruited at Lund University, Sweden. NLR levels were compared between patients with SLE and healthy controls (n=79). The relationship between NLR and clinical and immunological markers was examined using Mann-Whitney U test and logistic regression analysis. High NLR was defined as above the 90th percentile of healthy individuals.Results Patients with SLE had elevated neutrophil count (p=0.04) and reduced lymphocyte count (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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