| Autor: |
Guan Wang, Xi Kang, Katherine S. Chen, Tiffany Jehng, Lindsey Jones, Jie Chen, Xue F. Huang, Si-Yi Chen |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-020-15229-5 |
| Popis: |
Oncolytic viruses can activate tumor neoantigen-specific T cell responses. However, PD-L1 upregulation on tumor cells and immune cells leads to tumor resistance to this immunotherapy approach. Here, the authors develop an oncolytic virus which expresses both a PD-L1 inhibitor and GM-CSF which allows an improved tumor neoantigen-specific T cell response in preclinical models. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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