| Autor: |
Gerónimo Gutiérrez, Sabrina M. Rodríguez, Alix de Brogniez, Nicolas Gillet, Ramarao Golime, Arsène Burny, Juan-Pablo Jaworski, Irene Alvarez, Lucas Vagnoni, Karina Trono, Luc Willems |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Viruses, Vol 6, Iss 6, Pp 2416-2427 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1999-4915 |
| DOI: |
10.3390/v6062416 |
| Popis: |
Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
