A general mechanism of ribosome dimerization revealed by single-particle cryo-electron microscopy

Autor: Linda E. Franken, Gert T. Oostergetel, Tjaard Pijning, Pranav Puri, Valentina Arkhipova, Egbert J. Boekema, Bert Poolman, Albert Guskov
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-00718-x
Popis: When bacteria enter the stationary growth phase, protein translation is suppressed via the dimerization of 70S ribosomes into inactive complexes. Here the authors provide a structural basis for how the dual domain hibernation promotion factor promotes ribosome dimerization and hibernation in bacteria.
Databáze: Directory of Open Access Journals