NEW PLAYERS IN ALTERED TOLERANCE TO THYROID GLAND ANTIGENS: AN IMMUNOPATHOGENESIS CONCEPT OF AUTOIMMUNE THYROID DISEASE (REVIEW)

Autor:	V. V. Zdor, E. V. Markelova, B. I. Geltser
Jazyk:	ruština
Rok vydání:	2016
Předmět:	self-antigens tolerance thyrocytes autoantibodies mast cell cytokines Immunologic diseases. Allergy RC581-607
Zdroj:	Медицинская иммунология, Vol 18, Iss 3, Pp 209-220 (2016)
Druh dokumentu:	article
ISSN:	1563-0625 2313-741X
DOI:	10.15789/1563-0625-2016-3-209-220
Popis:	Precise mechanisms of tolerance loss to thyroid auto-antigens are still largely unknown, thus preventing further elucidation of key pathogenetic stages in autoimmune diseases affecting thyroid gland, and, therefore, to identify target pathways for treatment of these disorders. Detailed studies on the role of innate and adaptive immune cells in disturbed tolerance to autoantigens specific for thyroid gland in Graves’ disease and autoimmune Hashimoto’s thyroiditis have revealed and provided a number of theoretical foundations for arrangement of clinical immunological monitoring and forecasting of these diseases in a long-term prospective.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/397475bfb6074fe69c7748bd1359f70c Zobrazit plný text záznamu View record in DOAJ