Liver scaffolds obtained by decellularization: A transplant perspective in liver bioengineering

Autor: Marlon Lemos Dias, Bruno Andrade Paranhos, Regina Coeli dos Santos Goldenberg
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Tissue Engineering, Vol 13 (2022)
Druh dokumentu: article
ISSN: 2041-7314
20417314
DOI: 10.1177/20417314221105305
Popis: Liver transplantation is the only definitive treatment for many diseases that affect this organ, however, its quantity and viability are reduced. The study of liver scaffolds based on an extracellular matrix is a tissue bioengineering strategy with great application in regenerative medicine. Collectively, recent studies suggest that liver scaffold transplantation may assist in reestablishing hepatic function in preclinical diseased animals, which represents a great potential for application as a treatment for patients with liver disease in the future. This review focuses on useful strategies to promote liver scaffold transplantation and the main open questions about this context. We outline the current knowledge about ex vivo bioengineered liver transplantation, including the surgical techniques, recipient survival time, scaffold preparation before transplantation, and liver disease models. We also highlight the current limitations and future directions regarding in vivo bioengineering techniques.
Databáze: Directory of Open Access Journals
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