Evaluation of the combined effects of doxorubicin and bortezomib on the human acute lymphoblastic leukemia cell line
| Autor: | Korga Agnieszka, Humeniuk Ewelina, Adamczuk Grzegorz, Iwan Magdalena, Ostrowska Marta, Luszczewska-Sierakowska Iwona, Dudka Jarosław |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Current Issues in Pharmacy and Medical Sciences, Vol 32, Iss 2, Pp 87-91 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2084-980X 2300-6676 |
| DOI: | 10.2478/cipms-2019-0017 |
| Popis: | Increasing numbers of oncological patients and growing drug resistance ensure that new methods of cancer treatment are intensively sought. Combining drugs for a synergistic effect is one of several possible ways to mitigate this problem. This leads to reducing the effective drug dose and the occurrence of side effects. Doxorubicin (DOX) is an antineoplastic agent that has several mechanisms of action. DOX intercalates between base pairs of DNA helix, inhibits topoisomerase II and also forms reactive oxygen species. Bortezomib (BZT) is an antitumor agent belonging to the group of proteasome inhibitors. It has been observed that BZT triggers an oxidative stress response in vitro and in vivo. |
| Databáze: | Directory of Open Access Journals |
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