Long-Term Remission in a Case of Anaplastic Thyroid Carcinoma following Local Irradiation and High-Dose Chemotherapy with Autologous Peripheral Blood Stem Cell Transplantation

Autor: Koji Kato, Yuju Ohno, Shoshu Mitsuyama, Satoshi Toyoshima, Junichi Ito, Hisashi Gondo, Mine Harada
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Zdroj: Clinical Medicine Insights: Oncology, Vol 1 (2007)
Druh dokumentu: article
ISSN: 1179-5549
DOI: 10.4137/CMO.S435
Popis: Anaplastic thyroid carcinoma (ATC) is a tumor with bad prognosis and long-term survival is very low. However, appropriate combinations of chemotherapy, surgery, and radition have been reported to potentially improve the treatment results for ATC. We describe a case of refractory ATC successfully treated with high-dose chemotherapy (HDC) followed by autologous peripheral blood stem cell transplantation (auto-PBSCT). There has not been any evidence of recurrence for 10 years after auto-PBSCT. To the best of our knowledge, this is the first case of ATC that has been followed up for a long-term period after HDC with auto-PBSCT. This case suggests that intensive therapeutic approach such as HDC with auto-PBSCT may be useful.
Databáze: Directory of Open Access Journals