Fixel-based evidence of microstructural damage in crossing pathways improves language mapping in Post-stroke aphasia
| Autor: | Jie Zhang, Weihao Zheng, Desheng Shang, Yating Chen, Shuchang Zhong, Jing Ye, Lingling Li, Yamei Yu, Li Zhang, Ruidong Cheng, Fangping He, Dan Wu, Xiangming Ye, Benyan Luo |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | NeuroImage: Clinical, Vol 31, Iss , Pp 102774- (2021) |
| Druh dokumentu: | article |
| ISSN: | 2213-1582 38932148 |
| DOI: | 10.1016/j.nicl.2021.102774 |
| Popis: | Background: The complex crossing-fiber characteristics in the dual-stream system have been ignored by traditional diffusion tensor models regarding disconnections in post-stroke aphasia. It is valuable to identify microstructural damage of crossing-fiber pathways and reveal accurate fiber-specific language mapping in patients with aphasia. Methods: This cross-sectional study collected magnetic resonance imaging data from 29 participants with post-stroke aphasia in the subacute stage and from 33 age- and sex-matched healthy controls. Fixel-based analysis was performed to examine microstructural fiber density (FD) and bundle cross-section alterations of specific fiber populations in crossing-fiber regions. Group comparisons were performed, and relationships with language scores were assessed. Results: The aphasic group exhibited significant fixel-wise FD reductions in the dual-stream tracts, including the left inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus, and superior longitudinal fasciculus (SLF) III (family-wise-error-corrected p |
| Databáze: | Directory of Open Access Journals |
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