Severe Vitamin K-dependent Coagulopathy from Rodenticide-contaminated Synthetic Cannabinoids: Emergency Department Presentations

Autor: Erik Wright, John W. Hafner, Gregory Podolej, Douglas L. Feinstein, Richard van Breemen, Israel Rubinstein, Steven Aks, Michael Wahl
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Western Journal of Emergency Medicine, Vol 22, Iss 4 (2021)
Druh dokumentu: article
ISSN: 1936-9018
DOI: 10.5811/westjem.2021.2.46317
Popis: Introduction: Synthetic cannabinoids are a rapidly expanding subset of designer drugs widely available in the United States since 2008. In Illinois during the spring of 2018, over 160 documented cases of bleeding and prolonged coagulopathy occurred secondary to contaminated synthetic cannabinoids. Methods: We conducted a retrospective cohort study consisting of 38 patients to describe the initial emergency department (ED) presentation, diagnosis, and treatment. Results: Through serum testing we found that three long-acting anticoagulant rodenticides (LAAR) were detected in patients who had inhaled these tainted products: brodifacoum, difenacoum, and bromodialone. Discussion: This study encompasses the largest ED presentation of LAAR poisoning via the inhalational route known to date. Conclusion: The emergency physician should be aware of the potential for tainted coingestants as the cause of undifferentiated coagulopathy.
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