A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria

Autor: Iqbal Kamran, Bhargava Kapil, Skov Per, Falkencrone Sidsel, Grattan Clive EH
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Clinical and Translational Allergy, Vol 2, Iss 1, p 19 (2012)
Druh dokumentu: article
ISSN: 2045-7022
DOI: 10.1186/2045-7022-2-19
Popis: Abstract The electronic records of 398 patients with chronic spontaneous urticaria (CSU) who had had a serum basophil histamine release assay (BHRA) performed as a marker of functional autoantibodies were audited. The BHRA was positive in 105 patients (26.4%). Fifty eight were treated with ciclosporin because they were H1 anti-histamine unresponsive. CSU patients with a positive BHRA were more likely to respond clinically (P
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