| Autor: |
Giuseppina Calvaruso, Marta Chiavetta, Disma Renda, Simona Raso, Francesco Dieli, Vincenzo Luca Lentini, Massimo Gentile, Antonio Carroccio, Aurelio Maggio |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Thalassemia Reports, Vol 12, Iss 2, Pp 46-50 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2039-4365 |
| DOI: |
10.3390/thalassrep12020009 |
| Popis: |
Background: Haemophagocytic lymphohistiocytosis (HLH) is a rare and potentially life-threatening systemic hyperinflammatory disease, which can have several aetiologies. Clinical case: a 48-year-old woman affected by a transfusion-dependent β-thalassemia was hospitalized in our haematology unit presenting with intermittent fever, haepatosplenomegaly and pancytopenia, which developed a few days after the booster dose of anti-SARS-CoV-2 mRNA vaccine. The investigations performed during hospitalization led to a diagnosis of HLH and steroid therapy where IV dexamethasone was initiated and provided benefits. Conclusions: the severity of HLH mandates early treatment, but the management of patients with post-vaccine HLH is still challenging and requires further study. No cases of HLH in patients with thalassemia were previously described. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
