Novel Prostate Cancer Biomarkers: Aetiology, Clinical Performance and Sensing Applications

Autor: Tomas Bertok, Aniko Bertokova, Stefania Hroncekova, Erika Chocholova, Natalia Svecova, Lenka Lorencova, Peter Kasak, Jan Tkac
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Chemosensors, Vol 9, Iss 8, p 205 (2021)
Druh dokumentu: article
ISSN: 2227-9040
DOI: 10.3390/chemosensors9080205
Popis: The review initially provides a short introduction to prostate cancer (PCa) incidence, mortality, and diagnostics. Next, the need for novel biomarkers for PCa diagnostics is briefly discussed. The core of the review provides details about PCa aetiology, alternative biomarkers available for PCa diagnostics besides prostate specific antigen and their biosensing. In particular, low molecular mass biomolecules (ions and metabolites) and high molecular mass biomolecules (proteins, RNA, DNA, glycoproteins, enzymes) are discussed, along with clinical performance parameters.
Databáze: Directory of Open Access Journals