Contribution of glomerular morphometry to the diagnosis of pediatric nephropathies

Autor: Mariana Barreto Marini, Laura Penna Rocha, Juliana Reis Machado, Fernando Silva Ramalho, Marlene Antônia dos Reis, Rosana Rosa Miranda Corrêa
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Saudi Journal of Kidney Diseases and Transplantation, Vol 27, Iss 3, Pp 493-499 (2016)
Druh dokumentu: article
ISSN: 1319-2442
DOI: 10.4103/1319-2442.182382
Popis: Only a few studies describe histopathological changes in renal biopsies performed in pediatric patients. This study was conducted to identify an association between morphometric data in renal biopsies and renal function of these patients. Fifty-nine individuals with ages between 2 and 18 years old were selected, who were divided into six groups consisting of frequent nephropathies in children and adolescents and one control group. Proteinuria, urea, and creatinine values of the patients were recorded. Interactive image analysis software Leica QWin[®]was used for morpho- metric analysis of Bowman′s capsule, glomerular capillary tuft, and Bowman′s space area. The mean glomerular tuft area was higher in the membranous glomerulopathy group than in the podo- cytopathy group (57,101 ± 25,094 vs. 27,420 c ± 6279 µm2; P
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