| Autor: |
Olubukola Benedicta Ojo, Grace Boluwatife Olagunju, Abigail Oladunni Olajide, Muyiwa Emmanuel Jegede, Adewale Stephen Fakorede, Olamide Olajusi Crown, Mary Tolulope Olaleye, Afolabi Clement Akinmoladun |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Phytomedicine Plus, Vol 2, Iss 1, Pp 100196- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0313 |
| DOI: |
10.1016/j.phyplu.2021.100196 |
| Popis: |
Background: Stroke remains a leading cause of mortality and morbidity worldwide. Ischemic stroke is the most prevalent type of stroke and it is characterized by increased oxidative stress and other pathophysiological processes resulting from the reduction of blood flow to the brain. Medicinal plants have been reported to protect against oxidative stress and possess therapeutic potential for the management of stroke. In particular, Spondias mombin leaf extracts have been reported to possess antioxidant and neuroprotective properties. However, the ability of Spondias mombin leaf extract to protect distant organs against ischemicstroke mediated oxidative stress is not yet established. This study therefore evaluated the protective effects of Spondias mombin leaf extract (SML) on bilateral common carotid artery occlusion/reperfusion (BCCAO/R) ischemicstroke model-induced cardiac, hepatic, and renal oxidative stress in rats. Method: Male Wistar rats underwent 30 min of BCCAO and 24 h of reperfusion. Some groups of animals were post-treated with SML (25–100 mg/kg) or quercetin (20 mg/kg). Markers of oxidative stress were evaluated in the heart, liver, and kidney of the experimental animals. Results: BCCAO/R significantly (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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