Durable and controlled depletion of neutrophils in mice

Autor: Gael Boivin, Julien Faget, Pierre-Benoit Ancey, Aspasia Gkasti, Julie Mussard, Camilla Engblom, Christina Pfirschke, Caroline Contat, Justine Pascual, Jessica Vazquez, Nathalie Bendriss-Vermare, Christophe Caux, Marie-Catherine Vozenin, Mikael J. Pittet, Matthias Gunzer, Etienne Meylan
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-16596-9
Popis: Anti-Ly6G or ant-Gr1 antibodies are commonly used to deplete neutrophils in vivo. Here the authors provide mechanistic insight into why these approaches may not specifically or durably reduce the number of neutrophils in mice, and also present a new method that overcomes these limitations to have potentially wide applicability in experimental studies.
Databáze: Directory of Open Access Journals