Prevalence of multimorbidity and polypharmacy among adults and older adults: a systematic review

Autor: Kathryn Nicholson, PhD, Winnie Liu, BSc, Daire Fitzpatrick, MD, Kate Anne Hardacre, BMSc, Sarah Roberts, MD, Jennifer Salerno, PhD, Saverio Stranges, ProfMD PhD, Martin Fortin, MD MSc, Dee Mangin, ProfMBCHB DPH
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: The Lancet. Healthy Longevity, Vol 5, Iss 4, Pp e287-e296 (2024)
Druh dokumentu: article
ISSN: 2666-7568
DOI: 10.1016/S2666-7568(24)00007-2
Popis: Summary: Multimorbidity (multiple conditions) and polypharmacy (multiple medications) are increasingly common, yet there is a need to better understand the prevalence of co-occurrence. In this systematic review, we examined the prevalence of multimorbidity and polypharmacy among adults (≥18 years) and older adults (≥65 years) in clinical and community settings. Six electronic databases were searched, and 87 studies were retained after two levels of screening. Most studies focused on adults 65 years and older and were done in population-based community settings. Although the operational definitions of multimorbidity and polypharmacy varied across studies, consistent cut-points (two or more conditions and five or more medications) were used across most studies. In older adult samples, the prevalence of multimorbidity ranged from 4·8% to 93·1%, while the prevalence of polypharmacy ranged from 2·6% to 86·6%. High heterogeneity between studies indicates the need for more consistent reporting of specific lists of conditions and medications used in operational definitions.
Databáze: Directory of Open Access Journals