| Autor: |
Lei Chen, Maojun Yao, Xiaoyun Fan, Xiujun Lin, Randolph Arroo, Aline Silva, Bunleu Sungthong, Simona Dragan, Paolo Paoli, Shaoyun Wang, Hui Teng, Jianbo Xiao |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
eFood, Vol 1, Iss 2 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3066 |
| DOI: |
10.2991/efood.k.200207.001 |
| Popis: |
Dihydromyricetin (DHM) dramatically improved the quality of life for Streptozotocin (STZ)-induced diabetic rats and significantly increased the activity of antioxidant enzymes in the liver. Moreover, DHM successfully ameliorated diabetes-induced liver damage by suppression of apoptosis in the liver, as indicated by the decreased levels of Bax and cleaved caspase-3. In diabetic rats, the levels of tumor necrosis factor-α and interleukin-1β in the liver were significantly increased. However, the administration of DHM (100–400 mg/kg/day) for 6 weeks restored the cytokine levels to their normal values in a dose-dependent manner in diabetic rats by the regulation of nuclear factor-kappa B signaling pathway. In addition, DHM significantly induced 5′ AMP-activated protein kinase (AMPK) phosphorylation and decreased MyD88, TLR4, p38, GSK-3β protein expression levels in the liver of diabetic rats. In conclusion, DHM could improve STZ-induced liver impairment by preventing oxidative stress, apoptosis, and inflammation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text