| Autor: |
Ireneusz Połać, Bożena Góralczyk, Andrzej Kulig, Marek Zadrożny, Jakub Baszczyński, Beata Smolarz, Hanna Romanowicz, Tomasz Pertyński |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Menopause Review, Vol 15, Iss 1, Pp 10-14 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1643-8876 |
| Popis: |
Background: Single nucleotide polymorphisms in the DNA repair genes have been extensively studied inassociation with various human cancers such as breast cancer. Material and methods: We investigated an association of polymorphisms in the DNA repair genesXRCC2-Arg188His and RAD51-135G/C with the breast cancer risk. Genotypes were analysed by PCR-RFLP assaysin 80 patients with breast cancer and 80 controls. Results: The distribution of the genotypes of XRCC2 Arg188His in both controls and patients did not differsignificantly (p > 0,05) from those predicted by the Hardy-Weinberg distribution. The C/C genotype of RAD51increased the risk of breast cancer occurrence (OR 2.29; 95% PU (0.91–5.72), p = 0.04). Conclusion: G135C polymorphism of the RAD51 gene may be associated with the incidence of sporadicbreast cancer in Polish women. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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