NRAS-driven melanoma: A RAF can hide another

Autor:	Sabine Druillennec, Celio Pouponnot, Alain Eychène
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	araf braf craf ras human melanoma mouse resistance tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)
Druh dokumentu:	article
ISSN:	2372-3556 23723556
DOI:	10.1080/23723556.2017.1344758
Popis:	Using mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast, RAF proteins display compensatory functions in fully established tumors and ARAF can sustain proliferation in the absence of BRAF and CRAF, highlighting an addiction to RAF signaling in NRAS-driven melanoma.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3580f8ca3fb04b6897b2b04e64ae9c72 Zobrazit plný text záznamu View record in DOAJ