Metabolic flare phenomenon mimicking disease progression on 18Flouride– Fluorodeoxyglucose PET/CT scan in breast cancer treated with paclitaxel-based chemotherapy
| Autor: | Vijay Singh, Shivangi Dixit, Manish Ora, Aftab Nazar |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Asia Oceania Journal of Nuclear Medicine and Biology, Vol 11, Iss 2, Pp 175-180 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2322-5718 2322-5726 |
| DOI: | 10.22038/aojnmb.2022.68237.1474 |
| Popis: | 18F-fluorodeoxyglucose Positron emission tomography (18F-FDG PET/CT ) is now being used as a single modality for metastatic workup and response evaluation in breast cancer. An increase in metabolic activity indicates disease progression; however, metabolic flare should be kept in mind. Metabolic flare is a well-documented phenomenon reported in metastatic breast and prostate cancer. Despite a favorable response to therapy, there is a paradoxical increase in radiopharmaceutical uptake. The flare phenomenon with various chemotherapeutic and hormonal agents is well acknowledged in bone scintigraphy. However, very few cases have been documented on PET/CT. Increased uptake may be noted after treatment is instituted. The increased osteoblastic activity is associated with the healing response of bone tumors. We report a case of treated breast cancer. She presented with metastatic recurrence after four years of initial management. The patient was started on paclitaxel chemotherapy. Serial 18F- FDG PET/CT demonstrated metabolic flare and complete metabolic response. |
| Databáze: | Directory of Open Access Journals |
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