| Autor: |
Jessie E. Wozniak, Aroon T. Chande, Eileen M. Burd, Victor I. Band, Sarah W. Satola, Monica M. Farley, Jesse T. Jacob, I. King Jordan, David S. Weiss |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Antibiotics, Vol 9, Iss 11, p 825 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2079-6382 |
| DOI: |
10.3390/antibiotics9110825 |
| Popis: |
Colistin is an important last-line antibiotic to treat highly resistant Enterobacter infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical Enterobacter isolate with a deletion of mgrB, a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests colistin resistance could become more common in Enterobacter. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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