Antimicrobial susceptibility pattern of Acinetobacter isolates from patients in Kenyatta National Hospital, Nairobi, Kenya

Autor: Victor Moses Musyoki, Moses Muia Masika, Winnie Mutai, Gitau Wilfred, Antony Kuria, Felista Muthini
Jazyk: English<br />French
Rok vydání: 2019
Předmět:
Zdroj: The Pan African Medical Journal, Vol 33, Iss 146 (2019)
Druh dokumentu: article
ISSN: 1937-8688
DOI: 10.11604/pamj.2019.33.146.17220
Popis: INTRODUCTION: Infection due to multidrug-resistant microorganisms is a growing threat in healthcare settings. Acinetobacter species specifically A. baumannii is increasingly becoming resistant to most antimicrobial agents recommended for treatment. This study aimed to determine the antimicrobial susceptibility pattern of Acinetobacter species isolated from patients in Kenyatta National Hospital. METHODS: We conducted a retrospective study based on VITEK 2 (BioMrieux) electronic records capturing identification and antimicrobial susceptibility of Acinetobacter isolates from patient samples analyzed between 2013 and 2015 at Kenyatta National Hospital microbiology laboratory. Generated data were analyzed using WHONET and SPSS. RESULTS: A total of 590 Acinetobacter isolates were analyzed. 85% of the isolates tested were multi-drug resistant (MDR). Among the 590 isolates, 273 (46%) were from tracheal aspirates and 285 (48%) from the critical care unit. A. baumannii was the most frequently isolated species with high susceptibility to amikacin (77%) and poor susceptibility to ciprofloxacin (69-76%), tobramycin (37%) and meropenem (27%). Both A. lwoffii and A. haemolyticus had high susceptibility to amikacin (80-100%) and meropenem (75-100%).
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