Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct

Autor: Luis A. Ortiz-Rodríguez, Christian Reichardt, Sean J. Hoehn, Steffen Jockusch, Carlos E. Crespo-Hernández
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-17333-y
Popis: The mechanisms of formation of the (6-4) photoproducts in DNA damage by sunlight is still debated. Here the authors show, by optical spectroscopies and computations, the details of the formation of a (6-4) photoadduct via the thietane intermediate in a single-stranded DNA oligonucleotide.
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