An efficient synthesis of styryl 1,3,4-thiadiazoles using Lawesson’s reagent and Propylphosphonic anhydride-precursors for bis heterocycles

Autor: Mallikarjuna Reddy Guda, Sravya Gundala, Padmavathi Venkatapuram, Padmaja Adivireddy
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Arabian Journal of Chemistry, Vol 7, Iss 6, Pp 947-954 (2014)
Druh dokumentu: article
ISSN: 1878-5352
DOI: 10.1016/j.arabjc.2014.08.013
Popis: The compounds styryl 1,3,4-thiadiazoles were prepared adopting one and two step methodologies to optimize the yield of the products. The two-step methodology via benzohydrazide followed by treatment with Lawesson’s reagent in the presence of Propylphosphonic anhydride and triethylamine produced styryl 1,3,4-thiadiazoles in excellent yields. The olefin moiety in these compounds is utilized to develop pyrazole and isoxazole rings by 1,3-dipolar cycloaddition methodology followed by oxidation.
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