Impact of risk factors in developing bronchial asthma combined with gastroesophageal reflux disease in children

Autor: T.R. Umanets, A.A. Buratynska, S.I. Tolkach, L.S. Stepanova, S.Yu. Matveeva, T.V. Kondratenkova, O.A. Smirnova, T.A. Garaschenko, V.F. Lapshyn, Yu.G. Antipkin
Jazyk: English<br />Ukrainian
Rok vydání: 2020
Předmět:
Zdroj: Medičnì Perspektivi, Vol 25, Iss 4, Pp 121-127 (2020)
Druh dokumentu: article
ISSN: 2307-0404
DOI: 10.26641/2307-0404.2020.4.221399
Popis: The purpose of the study was to determine the risk factors affecting the development of asthma combined with gastroesophageal reflux disease (GERD). Seventy children aged 5-17 years with asthma were examined. They were divided to two groups: group 1 (50 children with asthma and GERD), and group 2 (20 children with isolated asthma). Medical history data were collected through specially designed questionnaire for parents. It was determined that the perinatal risk factors that likely contributed to developing co-morbid asthma and GERD were a threatened miscarriage (OR=6.65; 95% CI, 1.7-25.6, p=0.003), acute respiratory illnesses during pregnancy (OR=6.52; 95% CI, 1.4-31.2, p=0.008), polyhydramnios (p=0.039) and uterine inertia (p=0.0003). Food hypersensitivity in the first year of life, the severity of asthma in examined children played role in increasing the risk of developing asthma combined with GERD (OR=4.83; 95% CI, 1.3-18.6, p=0.013 and OR=4.45; 95% CI, 1.2-17.1, р=0.019 respectively).
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