| Autor: |
Michael E. Kallen, Rima Koka, Zeba N. Singh, Yi Ning, Mehmet H. Kocoglu, Ashraf Z. Badros, Sandrine Niyongere, Vu H. Duong, Ashkan Emadi, Maria R. Baer |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Leukemia Research Reports, Vol 18, Iss , Pp 100358- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2213-0489 |
| DOI: |
10.1016/j.lrr.2022.100358 |
| Popis: |
New therapies for multiple myeloma have improved outcomes, but are associated with therapy-related hematologic malignancies. We report eight patients with therapy-related B-lymphoblastic leukemias (t-B-ALL) in the setting of therapy for multiple myeloma, which included lenalidomide maintenance. A subset of patients had pancytopenia and low-level marrow involvement by acute leukemia, an unusual finding in de novo B-ALL. One patient died of chemotherapy complications; the other seven responded. No patient died of B-ALL (median follow up of 1.0 years). Our series suggests that t-B-ALL is clonally unrelated to myeloma, presents with diverse cytogenetic abnormalities, and responds well to B-ALL therapy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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